Atropine eye drops control myopia, will affect intraocular pressure

Abstract: among the short-term adverse reactions, intraocular pressure and glaucoma related problems attract the most attention: Although there are reports that atropine causes acute angle closure glaucoma, it is also pointed out that atropine and other anticholinergic drugs will not cause acute angle closure glaucoma without pre-existing anatomical abnormalities such as shallow anterior chamber.

atropine – myopia prevention and control –

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it is well known that atropine is a muscarinic receptor antagonist – topical application of atropine can relax the pupil sphincter and ciliary muscle, dilate the pupil and regulate paralysis. Topical atropine has been successfully used to prevent the progression of myopia in Taiwan since 1997. In fact, it has become the mainstream method of myopia prevention and control in Asia.

adverse reactions –

however, parents are always worried that the adverse reactions of atropine will cause harm to children. These adverse reactions can be divided into short-term adverse reactions and long-term adverse reactions. The short-term adverse reactions of

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include red eye, photophobia, blurred vision, allergic dermatitis, possible increase of intraocular pressure and attack of acute angle closure glaucoma. The long-term adverse reactions of

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include drug-induced amnesia, drowsiness, convulsions, memory impairment, etc.

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are the most concerned – intraocular pressure – among the short-term adverse reactions of

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, the problems related to intraocular pressure and glaucoma are the most concerned: Although there are reports that atropine causes acute angle closure glaucoma, it is also pointed out that atropine and other anticholinergic drugs will not cause acute angle closure glaucoma without pre-existing anatomical abnormalities such as shallow anterior chamber.

however, it is still unclear whether atropine can cause elevated intraocular pressure. The appropriate dosage concentration is also controversial. The concentration of

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atropine varies. What is the effect The purpose of

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is to evaluate the effect of different concentrations of atropine on intraocular pressure in school-age children in Taiwan and the effect of controlling the progression of low-grade myopia. The researchers of

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divided 56 Taiwan children with myopia into three groups. 32 children received atropine eye drops with a concentration of 0.125%, 12 children received atropine eye drops with a concentration of 0.25%, and the other 12 children served as the control group. There was no difference in average age, gender composition, baseline IOP and baseline equivalent sphericity among the three groups. The patients were followed up for 1 year, and the equivalent sphericity and intraocular pressure were examined every 3 months. There was no significant difference between

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and baseline intraocular pressure in the three groups at the last follow-up, that is, atropine could not be considered to have an effect on subjects’ intraocular pressure. Myopia in the

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control group progressed significantly (compared with the 0.125% atropine concentration group) from 6 months after treatment to the end of follow-up. At the last follow-up of

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, the mean difference between the equivalent sphericity of the 0.125% and 0.25% group and the control group and the baseline was? 0.05D,0D,? 1.05d, it can be seen that 0.125% and 0.25% atropine can significantly delay the progression of myopia.

our study pointed out that within 1 year, there was no evidence that atropine was related to elevated intraocular pressure. Similar to other studies, atropine can indeed control the progression of myopia, even if it is applied at a low concentration of 0.125%. Many adverse reactions of atropine local eye drops still need to be clarified by large-scale, double-blind and long-term clinical studies in the future.