Etiology and pathogenesis of myopia TCM syndrome differentiation theory and treatment

Abstract: on the basis of summarizing the previous academic experience of “tonifying the liver and kidney” in juvenile myopia, through systematic clinical research, we found that the external manifestation of juvenile myopia is “the loss of meridians and Qi, and the more hindered the development of divine light”, and the viscera, especially the “deficiency of kidney yang” is the key factor.

expounds the etiology and pathogenesis of myopia, puts forward the pathogenesis theory of “deficiency of kidney yang, loss of meridian qi and restraint of divine light” for juvenile low vision, establishes the syndrome differentiation and treatment principle of “warming kidney and benefiting essence, publicizing meridian qi and increasing divine light”, and reveals the vital role of kidney yang and meridian qi in juvenile low vision eye diseases, It puts forward the method of syndrome differentiation and treatment of “warming the kidney and benefiting essence, publicizing meridians and Qi, and getting more divine light”.

in recent years, the younger age trend of myopia is becoming more and more serious, and has become the primary cause of visual disability all over the world. It is urgent to prevent juvenile myopia and explore its related factors. An epidemiological survey involving 20000 students from 2008 to 2009 showed that the prevalence of myopia among primary school students, junior middle school students and senior high school students in China was 13.7%, 42.9% and 69.7% respectively, of which the prevalence of myopia among senior high school students in Shandong Province was as high as 87.3%. In addition, a survey on myopia shows that China has nearly 400 million myopia patients, ranking first in the world, 1.5 times the world average. The decline of teenagers’ visual health has significantly affected the overall health level of our citizens and greatly reduced China’s international competitiveness. This is not only a simple medical health problem, but also a serious social problem, which must be solved. The prevention and control of juvenile myopia has gradually attracted extensive attention from all walks of life. It is urgent to deeply understand the etiology, pathogenesis and treatment of myopia, which is of great significance to solve the problem of juvenile myopia.

however, the clinical prevention and treatment of the disease is very difficult, which is a worldwide problem. There are three major problems: first, the treatment of Western medicine at home and abroad mainly depends on refractive correction means such as glasses to improve vision, which can not effectively improve the pathological state of the eyeball, enhance visual function and inhibit the development of the disease; Second, although TCM treatment has advantages, the diagnosis and treatment methods lack unified theoretical guidance, and there is no systematic and standardized comprehensive diagnosis and treatment system; Third, the biological mechanism of traditional Chinese medicine in the treatment of low vision is still lack of systematic research, which is difficult to provide modern scientific and technological support for the formulation of more optimized diagnosis and treatment schemes and the research and development of key prevention and treatment technologies.

on the basis of in-depth summary of many years of clinical experience, we focus on giving full play to the advantages of traditional Chinese medicine in the prevention and treatment of low vision eye diseases in adolescents, deeply explore their etiology and pathogenesis through epidemiological investigation, clinical and basic series research, actively transform research results, and create a more effective diagnosis and treatment strategy and prevention and control system, It has established a diagnosis and treatment system for adolescents with low vision, put forward the pathogenesis theory of “deficiency of kidney yang, loss of meridian qi and restraint of divine light” and the syndrome differentiation and treatment principle of “warming kidney and benefiting essence, publicizing meridian qi and increasing divine light”, and revealed the vital role of kidney yang and meridian qi in adolescents with low vision.

1 Relationship between the eye and the meridians and kidneys

the “Lingshu evil Qi viscera disease form” says: “twelve meridians, 365 collaterals, their blood and Qi go up to the face and go through the empty orifices, and their essence and Yang Qi go up to the eyes and become the eyes.” It is suggested that there are many meridians connected with each other between the eyes and the viscera of the whole body, forming an organic whole with a certain connection. It is precisely because many meridians constantly transport blood to the eyes that the eyes can play a normal visual function. The criterion of syndrome treatment describes myopia in this way: “this syndrome is not due to myopia, but has no disease in the past. It can be hyperopia, but it can’t be in a hurry. It can’t cover Yang enough, Yin more than, and the disease has no fire. Therefore, Guanghua can’t go beyond the outside and converge myopia.” It shows that myopia is not only related to bad eye habits at ordinary times, but also the main cause originates from Zang Fu organs and meridians.

and

essence and Qi are the material basis for forming the human body and maintaining life activities. “Su Wen · ancient innocence theory” said: “the kidney governs the water and is hidden by the essence of the five zang organs”. “Lingshu · Da Hun Lun” said: “the eyes are the essence of the five zang organs”. It shows that the kidney governs the storage of essence, including congenital essence and acquired essence. The eyes are based on essence. The formation of the eyes and the visual function of the eyes depend on the cultivation of the essence and Qi of the five Zang Fu organs, especially the kidney. The rise and fall of the essence of the kidney directly affects the visual function of the eyes, that is, according to su Wen · on the essence of the pulse: “if you are smart, you should look at all things, not white and black, judge short and long; take long as short, and white as black, then essence will decline.”

kidney generates brain marrow and belongs to brain. “Su Wen · Yin Yang Ying Xiang Da Lun” says: “the kidney generates bone marrow”, and “Lingshu · Hai Lun” says: “the brain is the sea of marrow”. “Lingshu · Da Hun Lun” points out: “the eye belongs to the brain, and then comes out of the item, and the evil comes from the item… Then follow the eye to enter the brain, enter the brain to turn, turn the brain to lead the eye to be urgent, and turn the eye to be dizzy when the eye is urgent.” It is pointed out that the kidney governs the storage of essence, which can produce marrow and fill the brain. The brain is the medullary sea, which belongs to the brain in the order. If the kidney essence is sufficient, the viscera essence and Qi are full, and the marrow sea is abundant, the eye essence is sufficient and visible. The medical forest corrects mistakes points out that “the clear essence turns into marrow, which goes up from the spine into the brain, which is called brain marrow… The two eyes are like lines, longer than the brain, and the things seen belong to the brain”. It clearly expounds that there is a close internal relationship between kidney, brain and eye. If the kidney essence is insufficient, the essence is not solid, the marrow sea is empty, and the eyes lose nourishment, the vision will be dim. Therefore, “Lingshu · sea theory” said: “if the marrow sea is insufficient, the brain turns and tinnitus, and the eyes see nothing.”

and

kidney contain Yin and Yang and cultivate pupil spirit. The kidney is the viscera of fire and water, and the true Yin and the true Yang are the essence of yin and Yang. The Yang of the five viscera rises from this. The Yin of the five zang organs is nourished by this, and the essence of the kidney is to nourish the pupil. As the “review of Yao Han · theory of eyes as the most precious treasure” said: “the essence of the kidney rises, and the knot becomes a water wheel.” The water wheel is located in the pupil God and contains divine light. “Lingshu dahualun” said: “Yin and yang are combined and smart.” Yin and yang are the basis of visual acuity. The Yin and Yang contained in the kidney directly affect the visual function of the eye.

2 pathogenesis theory of “deficiency of kidney yang, loss of meridian qi and restraint of divine light

traditional Chinese medicine has long recorded myopia. It first mentioned” myopia “in the Dacheng of Mu Jing and called it” deficiency of spleen and kidney, endless discharge, and myopia “. “Chen Dafu’s clinical experience in ophthalmology of traditional Chinese medicine” mentioned that it is the liver that can be close and timid to be farThe longer the course of myopia, the older the age, the lower the cure rate, otherwise the greater the cure tendency.

a large number of clinical studies have confirmed that acupuncture has a good effect on myopia. By needling the meridians of the kidney meridians, we can promote the Qi of the kidney meridians, reach the brain and eyes, and make more spiritual light. Tao Xiaoyan’s research on acupuncture in the treatment of juvenile myopia shows that acupuncture at acupoints can generally improve the naked vision of myopia patients. Zhang Xue and others observed the clinical efficacy of acupuncture in the treatment of juvenile myopia. They selected Jingming, Sibai and Taiyang on the affected side as the main acupoints, and combined with zanzhu, Hegu, Xuehai, Taichong and Zusanli. The research confirmed that the total effective rate could be as high as 97.9%. In addition, Zhou Huaxiang’s experiment aims to explore the effect of acupuncture on the visual function of isolated fibers in rabbit optic nerve. The results show that the effect of electroacupuncture at Hegu and Taixi on flash electroretinogram is not through the descending inhibition of the center, but affects the isolated fibers, so as to have an impact on the retina to a limited extent.

and

are based on the treatment principle of “promoting meridians and Qi, and getting more divine light”. The author mainly uses acupuncture to treat adolescent patients with low vision. The results show that acupuncture can quickly adjust the movement of Qi and blood, dredge meridians, stimulate meridians and Qi, get more divine light, and significantly improve the myopia of adolescent patients, including naked eye vision, diopter The adjustment range and sensitivity were significantly improved after treatment (P < 0.01), and the total effective rate increased from 78.0% to 97.06% compared with the control group.

4 Conclusion

to sum up, “deficiency of kidney yang, loss of meridians and stagnation of Shenguang” are the basic pathogenesis of myopia, “deficiency of kidney yang and loss of meridians” It is the key pathogenesis of myopia. We explore the theoretical basis and clinical application of “warming the kidney and benefiting the essence, promoting meridians and Qi, and getting more divine light” in the treatment of myopia, so as to provide new ideas and methods for clinical diagnosis and treatment of the disease.

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, Abstract: on the basis of summarizing the previous academic experience of “tonifying the liver and kidney” in juvenile myopia, through systematic clinical research, we found that “loss of meridians and Qi and obstruction of Shenguang” are the external manifestations of juvenile myopia, and the viscera, especially “deficiency of kidney yang” is the key factor of the disease., This paper expounds the etiology and pathogenesis of myopia, puts forward the pathogenesis theory of “deficiency of kidney yang, loss of meridian qi and restraint of divine light” for juvenile low vision, establishes the syndrome differentiation and treatment principle of “warming kidney and benefiting essence, publicizing meridian qi and getting more divine light”, and reveals the vital role of kidney yang and meridian qi in juvenile low vision eye diseases, It puts forward the method of syndrome differentiation and treatment of “warming the kidney and benefiting essence, publicizing meridians and Qi, and getting more divine light”., In recent years, the younger age trend of myopia is becoming more and more serious, which has become the primary cause of visual disability all over the world. It is urgent to prevent juvenile myopia and explore its related factors. An epidemiological survey involving 20000 students from 2008 to 2009 showed that the prevalence of myopia among primary school students, junior middle school students and senior high school students in China was 13.7%, 42.9% and 69.7% respectively, of which the prevalence of myopia among senior high school students in Shandong Province was as high as 87.3%. In addition, a survey on myopia shows that China has nearly 400 million myopia patients, ranking first in the world, 1.5 times the world average. The decline of teenagers’ visual health has significantly affected the overall health level of our citizens and greatly reduced China’s international competitiveness. This is not only a simple medical health problem, but also a serious social problem, which must be solved. The prevention and control of juvenile myopia has gradually attracted extensive attention from all walks of life. It is urgent to deeply understand the etiology, pathogenesis and treatment of myopia, which is of great significance to solve the problem of juvenile myopia., However, the clinical prevention and treatment of the disease is very difficult, which is a worldwide problem. There are three major problems: first, the treatment of Western medicine at home and abroad mainly depends on refractive correction means such as glasses to improve vision, which can not effectively improve the pathological state of the eyeball, enhance visual function and inhibit the development of the disease; Second, although TCM treatment has advantages, the diagnosis and treatment methods lack unified theoretical guidance, and there is no systematic and standardized comprehensive diagnosis and treatment system; Third, there is still a lack of systematic research on the biological mechanism of traditional Chinese medicine in the treatment of low vision, which is difficult to provide modern scientific and technological support for the formulation of more optimized diagnosis and treatment schemes and the research and development of key prevention and treatment technologies.,

expounds the etiology and pathogenesis of myopia, puts forward the pathogenesis theory of “deficiency of kidney yang, loss of meridian qi and restraint of divine light” for juvenile low vision, establishes the syndrome differentiation and treatment principle of “warming kidney and benefiting essence, publicizing meridian qi and increasing divine light”, and reveals the vital role of kidney yang and meridian qi in juvenile low vision eye diseases, It puts forward the method of syndrome differentiation and treatment of “warming the kidney and benefiting essence, publicizing meridians and Qi, and getting more divine light”.

in recent years, the younger age trend of myopia is becoming more and more serious, and has become the primary cause of visual disability all over the world. It is urgent to prevent juvenile myopia and explore its related factors. An epidemiological survey involving 20000 students from 2008 to 2009 showed that the prevalence of myopia among primary school students, junior middle school students and senior high school students in China was 13.7%, 42.9% and 69.7% respectively, of which the prevalence of myopia among senior high school students in Shandong Province was as high as 87.3%. In addition, a survey on myopia shows that China has nearly 400 million myopia patients, ranking first in the world, 1.5 times the world average. The decline of teenagers’ visual health has significantly affected the overall health level of our citizens and greatly reduced China’s international competitiveness. This is not only a simple medical health problem, but also a serious social problem, which must be solved. The prevention and control of juvenile myopia has gradually attracted extensive attention from all walks of life. It is urgent to deeply understand the etiology, pathogenesis and treatment of myopia, which is of great significance to solve the problem of juvenile myopia.

however, the clinical prevention and treatment of the disease is very difficult, which is a worldwide problem. There are three major problems: first, the treatment of Western medicine at home and abroad mainly depends on refractive correction means such as glasses to improve vision, which can not effectively improve the pathological state of the eyeball, enhance visual function and inhibit the development of the disease; Second, although TCM treatment has advantages, the diagnosis and treatment methods lack unified theoretical guidance, and there is no systematic and standardized comprehensive diagnosis and treatment system; Third, the biological mechanism of traditional Chinese medicine in the treatment of low vision is still lack of systematic research, which is difficult to provide modern scientific and technological support for the formulation of more optimized diagnosis and treatment schemes and the research and development of key prevention and treatment technologies.

on the basis of in-depth summary of many years of clinical experience, we focus on giving full play to the advantages of traditional Chinese medicine in the prevention and treatment of low vision eye diseases in adolescents, deeply explore their etiology and pathogenesis through epidemiological investigation, clinical and basic series research, actively transform research results, and create a more effective diagnosis and treatment strategy and prevention and control system, It has established a diagnosis and treatment system for adolescents with low vision, put forward the pathogenesis theory of “deficiency of kidney yang, loss of meridian qi and restraint of divine light” and the syndrome differentiation and treatment principle of “warming kidney and benefiting essence, publicizing meridian qi and increasing divine light”, and revealed the vital role of kidney yang and meridian qi in adolescents with low vision.

1 Relationship between the eye and the meridians and kidneys

the “Lingshu evil Qi viscera disease form” says: “twelve meridians, 365 collaterals, their blood and Qi go up to the face and go through the empty orifices, and their essence and Yang Qi go up to the eyes and become the eyes.” It is suggested that there are many meridians connected with each other between the eyes and the viscera of the whole body, forming an organic whole with a certain connection. Because many meridians are constantlyThe normal visual function of the eyes can be brought into play only by transporting blood to the eyes. The criterion of syndrome treatment describes myopia in this way: “this syndrome is not due to myopia, but has no disease in the past. It can be hyperopia, but it can’t be in a hurry. It can’t cover Yang enough, Yin more than, and the disease has no fire. Therefore, Guanghua can’t go beyond the outside and converge myopia.” It shows that myopia is not only related to bad eye habits at ordinary times, but also the main cause originates from Zang Fu organs and meridians.

and

essence and Qi are the material basis for forming the human body and maintaining life activities. “Su Wen · ancient innocence theory” said: “the kidney governs the water and is hidden by the essence of the five zang organs”. “Lingshu · Da Hun Lun” said: “the eyes are the essence of the five zang organs”. It shows that the kidney governs the storage of essence, including congenital essence and acquired essence. The eyes are based on essence. The formation of the eyes and the visual function of the eyes depend on the cultivation of the essence and Qi of the five Zang Fu organs, especially the kidney. The rise and fall of the essence of the kidney directly affects the visual function of the eyes, that is, according to su Wen · on the essence of the pulse: “if you are smart, you should look at all things, not white and black, judge short and long; take long as short, and white as black, then essence will decline.”

kidney generates brain marrow and belongs to brain. “Su Wen · Yin Yang Ying Xiang Da Lun” says: “the kidney generates bone marrow”, and “Lingshu · Hai Lun” says: “the brain is the sea of marrow”. “Lingshu · Da Hun Lun” points out: “the eye belongs to the brain, and then comes out of the item, and the evil comes from the item… Then follow the eye to enter the brain, enter the brain to turn, turn the brain to lead the eye to be urgent, and turn the eye to be dizzy when the eye is urgent.” It is pointed out that the kidney governs the storage of essence, which can produce marrow and fill the brain. The brain is the medullary sea, which belongs to the brain in the order. If the kidney essence is sufficient, the viscera essence and Qi are full, and the marrow sea is abundant, the eye essence is sufficient and visible. The medical forest corrects mistakes points out that “the clear essence turns into marrow, which goes up from the spine into the brain, which is called brain marrow… The two eyes are like lines, longer than the brain, and the things seen belong to the brain”. It clearly expounds that there is a close internal relationship between kidney, brain and eye. If the kidney essence is insufficient, the essence is not solid, the marrow sea is empty, and the eyes lose nourishment, the vision will be dim. Therefore, “Lingshu · sea theory” said: “if the marrow sea is insufficient, the brain turns and tinnitus, and the eyes see nothing.”

and

kidney contain Yin and Yang and cultivate pupil spirit. The kidney is the viscera of fire and water, and the true Yin and the true Yang are the essence of yin and Yang. The Yang of the five viscera rises from this. The Yin of the five zang organs is nourished by this, and the essence of the kidney is to nourish the pupil. As the “review of Yao Han · theory of eyes as the most precious treasure” said: “the essence of the kidney rises, and the knot becomes a water wheel.” The water wheel is located in the pupil God and contains divine light. “Lingshu dahualun” said: “Yin and yang are combined and smart.” Yin and yang are the basis of visual acuity. The Yin and Yang contained in the kidney directly affect the visual function of the eye.

2 pathogenesis theory of “deficiency of kidney yang, loss of meridian qi and restraint of divine light

traditional Chinese medicine has long recorded myopia. It first mentioned” myopia “in the Dacheng of Mu Jing and called it” deficiency of spleen and kidney, endless discharge, and myopia “. Chen Dafu’s clinical experience in ophthalmology of traditional Chinese medicine mentioned that being able to be near and far away is due to lack of liver and kidney, deficiency of essence and blood, loss of nourishment of eyes, resulting in dereliction of duty and unfavorable Qi mechanism; The pathogenesis of myopia is expounded in the secret eye kelongmu theory. Although the eye belongs to the five internal organs, the kidney is the most expensive of the five internal organs. If the kidney qi fails, all the five internal organs will be ill. Attacking the disease of the eye is the most important. The vision of the eye depends on the essence and Qi of the kidney; Deficiency of liver and kidney, lack of essence and blood, resulting in the decline of divine light, the brilliance cannot be far away, or the weakness of heart Yang, the divine light cannot be far away.

on the basis of summarizing the previous academic experience of “tonifying the liver and kidney” in juvenile myopia, through systematic clinical research, we found that the external manifestation of juvenile myopia is “the loss of meridians and Qi, and the more blocked Shenguang hair”, and the viscera, especially the “deficiency of kidney yang” is the key factor. This understanding is related to “myopia is the lack of fire” (review Yao letter), “if the cover Yang is insufficient, the Yin is surplus, and the disease is caused by fire, the solid Guanghua can not go beyond the outside, but converge the myopia ear” (syndrome and treatment criteria), “if the cover energy myopia is not caused by hyperopia, the real fire is insufficient, and if the disease is caused by the disease, the Guanghua is restrained, and the real Yang in the kidney is not enough to return the light and shine on itself” (six essentials of Ophthalmology) “Myopia is clear and bright, hyperopia is faint, lack of sunlight is invaded by Yin” (Yizong Jinjian). In treatment, we should not only pay attention to local promotion of meridians, but also carry out whole-body conditioning with kidney yang as the core, so as to achieve good therapeutic effect, so as to create “deficiency of kidney yang, loss of meridians and Qi, and restraint of divine light” And puts forward the important role of kidney yang and meridian qi in the ophthalmopathy of juvenile low vision.

2.1 the constitution of kidney yang deficiency is closely related to the incidence of low vision in adolescents.

traditional Chinese medicine believes that the constitution is inherited from nature and raised after the day. Its state can reflect the strength and weakness of healthy qi in the body, determine whether it occurs, and the difference of constitution will lead to human susceptibility and tendency to myopia and other diseases, Thus, it constitutes the basis or background of these diseases. And modern research shows that deficiency syndrome is the main TCM syndrome differentiation type of myopia, in which kidney yang deficiency has high diopter and the incidence of macular disease. It can be seen that the occurrence and development of myopia is closely related to people’s physical state. People with deficiency syndrome constitution of traditional Chinese medicine seem to be more prone to myopia.

and

to this end, we carried out a large sample and multi center epidemiological study. 4574 people were tested, of which 4340 completed the questionnaire of traditional Chinese Medicine physique, and the overall test rate was 94.9%. According to the standard of classification and determination of traditional Chinese Medicine physique, it was found that young myopia was dominated by Yang deficiency, accounting for 28.03%, which was significantly higher than that of peace and other 8 abnormal physiques, It shows that Yang deficiency quality has tendency and susceptibility to myopia. Further research confirmed that the prevalence of myopia in children with Yang deficiency was as high as 65.2%, while the prevalence of peace and other 8 abnormal constitutions was only 23.1%.

2.2 experiments confirmed that animals with kidney yang deficiency were more prone to myopia

in the guinea pig model of myopia with kidney yang deficiency, it was found that the dry weight and thickness of sclera in the posterior pole of animals with kidney yang deficiency were lower than those in normal guinea pigs, the expression of MMP-2 in the posterior pole sclera was significantly increased, and the expression of TIMP-2 was significantly decreased, Compared with the model eyes in the simple myopia group, the myopia diopter and axial length in the kidney yang deficiency myopia group increased, which was more prone to myopia than that in the normal guinea pigs. Through the experimental study of the animal model of kidney yang deficiency, it is found that the hair of guinea pigs with kidney yang deficiency is haggard and tiredFoundation. “Su Wen · ancient innocence theory” said: “the kidney governs the water and is hidden by the essence of the five zang organs”. “Lingshu · Da Hun Lun” said: “the eyes are the essence of the five zang organs”. It shows that the kidney governs the storage of essence, including congenital essence and acquired essence. The eyes are based on essence. The formation of the eyes and the visual function of the eyes depend on the cultivation of the essence and Qi of the five zang organs, especially the kidney. The rise and fall of the essence of the kidney directly affects the visual function of the eyes, that is, according to Su Wen · on the essence of the pulse: “if you are smart, you should look at all things, not white and black, judge short and long; take long as short, and white as black, then essence will decline.”, The kidney produces brain marrow and belongs to the brain. “Su Wen · Yin Yang Ying Xiang Da Lun” says: “the kidney generates bone marrow”, and “Lingshu · Hai Lun” says: “the brain is the sea of marrow”. “Lingshu · Da Hun Lun” points out: “the eye belongs to the brain, and then comes out of the item, and the evil comes from the item… Then follow the eye to enter the brain, enter the brain to turn, turn the brain to lead the eye to be urgent, and turn the eye to be dizzy when the eye is urgent.” It is pointed out that the kidney governs the storage of essence, which can produce marrow and fill the brain. The brain is the medullary sea, which belongs to the brain in the order. If the kidney essence is sufficient, the viscera essence and Qi are full, and the marrow sea is abundant, the eye essence is sufficient and visible. The medical forest corrects mistakes points out that “the clear essence turns into marrow, which goes up from the spine into the brain, which is called brain marrow… The two eyes are like lines, longer than the brain, and the things seen belong to the brain”. It clearly expounds that there is a close internal relationship between kidney, brain and eye. If the kidney essence is insufficient, the essence is not solid, the marrow sea is empty, and the eyes lose nourishment, the vision will be dim. Therefore, Lingshu · on the sea says: “if the marrow sea is insufficient, the brain turns and tinnitus, and the eyes can’t see.”, The kidney contains Yin and Yang and conserves the pupil spirit. The kidney is the viscera of fire and water, and the true Yin and the true Yang are the essence of yin and Yang. The Yang of the five viscera rises from this. The Yin of the five zang organs is nourished by this, and the essence of the kidney is to nourish the pupil. As the “review of Yao Han · theory of eyes as the most precious treasure” said: “the essence of the kidney rises, and the knot becomes a water wheel.” The water wheel is located in the pupil God and contains divine light. “Lingshu dahualun” said: “Yin and yang are combined and smart.” Yin and yang are the basis of visual acuity. The Yin and Yang contained in the kidney directly affect the visual function of the eye., According to the pathogenesis theory of “deficiency of kidney yang, loss of meridians and Qi, and restraint of Shenguang”, Chinese medicine has long recorded myopia. In the Dacheng of Mu Jing, it is first mentioned that “myopia” and called it “deficiency of spleen and kidney, endless leakage, and therefore myopia”. Chen Dafu’s clinical experience in ophthalmology of traditional Chinese medicine mentioned that being able to be near and far away is due to lack of liver and kidney, deficiency of essence and blood, loss of nourishment of eyes, resulting in dereliction of duty and unfavorable Qi mechanism; The pathogenesis of myopia is expounded in the secret eye kelongmu theory. Although the eye belongs to the five internal organs, the kidney is the most expensive of the five internal organs. If the kidney qi fails, all the five internal organs will be ill. Attacking the disease of the eye is the most important. The vision of the eye depends on the essence and Qi of the kidney; Deficiency of liver and kidney, insufficient blood essence, resulting in the decline of divine light, the brilliance cannot be far away, or the weakness of heart Yang, the divine light cannot be far away., On the basis of summarizing the previous academic experience of “tonifying the liver and kidney” in juvenile myopia, through systematic clinical research, we found that the external manifestation of juvenile myopia is “loss of meridians and Qi, and more and more blocked divine light”, and the viscera, especially “deficiency of kidney yang” is the key factor. This understanding is related to “myopia is the lack of fire” (review Yao letter), “if the cover Yang is insufficient, the Yin is surplus, and the disease is caused by fire, the solid Guanghua can not go beyond the outside, but converge the myopia ear” (syndrome and treatment criteria), “if the cover energy myopia is not caused by hyperopia, the real fire is insufficient, and if the disease is caused by the disease, the Guanghua is restrained, and the real Yang in the kidney is not enough to return the light and shine on itself” (six essentials of Ophthalmology) “Myopia is clear and bright, hyperopia is faint, lack of sunlight is invaded by Yin” (Yizong Jinjian). In treatment, we should not only pay attention to local promotion of meridians, but also carry out whole-body conditioning with kidney yang as the core, so as to achieve good therapeutic effect, so as to create “deficiency of kidney yang, loss of meridians and Qi, and restraint of divine light” And puts forward the vital role of kidney yang and meridian qi in the ocular diseases of juvenile low vision., 2.1 the constitution of kidney yang deficiency is closely related to the incidence of low vision in adolescents. Traditional Chinese medicine believes that the constitution is inherited from nature and raised after the day. Its state can reflect the strength and weakness of healthy qi in the body and determine whether it occurs. The difference of constitution will lead to human susceptibility and tendency to myopia and other diseases, which constitutes the basis or background of these diseases. And modern research shows that deficiency syndrome is the main TCM syndrome differentiation type of myopia, in which kidney yang deficiency has high diopter and the incidence of macular disease. It can be seen that the occurrence and development of myopia is closely related to people’s physical state. People with deficiency syndrome constitution of traditional Chinese medicine seem to be more prone to myopia., To this end, we carried out a large sample and multi center epidemiological study. 4574 people were tested, of which 4340 completed the questionnaire of traditional Chinese medicine constitution, and the overall test rate was 94.9%. According to the standard of classification and determination of traditional Chinese medicine constitution, we found that young myopia was dominated by yang deficiency, accounting for 28.03%, which was significantly higher than that of peace and other 8 abnormal constitutions, It shows that Yang deficiency quality has tendency and susceptibility to myopia. Further studies have confirmed that the prevalence of myopia in children with Yang deficiency is as high as 65.2%, while the prevalence of peace and other 8 abnormal constitutions is only 23.1%., 2.2 experiments confirmed that kidney yang deficiency animals were more prone to myopia. In the kidney yang deficiency myopia guinea pig model, it was found that the dry weight and thickness of sclera in the posterior pole of kidney yang deficiency animals were lower than those in normal guinea pigs, the expression of matrix metalloproteinase-2 in the posterior pole sclera was significantly increased, and the expression of TIMP-2 was significantly reduced. The model eyes in the kidney yang deficiency myopia group were compared with those in the simple myopia group, Myopic diopter increased and axial length increased, which was more prone to myopia than normal guinea pigs. Through the experimental study of the animal model of kidney yang deficiency, it is found that the guinea pigs with kidney yang deficiency show similar “Exhaustion” phenomena such as withered hair, fatigue and laziness, bow back and squint, slow response, clear and long urination, and their body weight is significantly reduced, The concentrations of serum hormones triiodothyronine (FT3), free thyroxine (FT4) and testosterone (T) decreased significantly, and estradiol (E2) concentration increased significantly, and it was found that the diopter of the myopia group with kidney yang deficiency was increased, the ocular axis was longer, and the sclera thickness of the posterior pole decreased more significantly than that of the simple myopia group, which provided an objective basis for TCM syndrome differentiation and diagnosis. Clinical and experimental studies showed that kidney yang deficiency was closely related to the development of myopia, which was “kidney yang deficiency, loss of meridians and Qi, and restraint of Shenguang” Pathogenesis theory provides objective evidence, enriches and develops TCM pathogenesis theory, and lays a theoretical foundation for syndrome differentiation and treatment of the disease