Is it better to take fatty acids together to prevent amd?

Abstract: macular pigment is composed of several kinds of carotenes, of which lutein and zeaxanthin are the most important. It is speculated that macular pigment plays a protective role in the occurrence and progression of age-related macular lesions., Macular pigment is composed of several kinds of carotenes, of which lutein and zeaxanthin are the most important. It is speculated that macular pigment plays a protective role in the occurrence and progression of age-related macular lesions. One of the characteristics of macular pigment is its strong ability to absorb short wavelength blue light. Therefore, it can increase the visual acuity of macula and reduce the destructive photooxidation of light on neurosensory retina. Assuming that the formation of free radicals is the cause of age-related macular degeneration (AMD), the high concentration of macular pigment density may prevent light-induced oxidative damage, on the contrary, the decrease of its density will increase the risk of AMD. Recently, some researchers have discussed the role of omega-3 polyunsaturated fatty acid (PUFA) in the prevention of AMD. There are high levels of docosahexaenoic acid (DHA) in the outer disc membrane of photoreceptors. Although its role is not clear, it is believed that DHA and its precursor eicosapentaenoic acid (EPA) play an important role in the retina. Previous studies on the role of PUFA in the progression of AMD have not been conclusive. The recent age-related eye disease study 2 (areds2) shows that DHA + EPA has no beneficial effect on the progress of AMD. However, there are many supplements containing a large amount of Puma on the market, which are widely used to prevent and slow down the progress of AMD., Wolf schnurrbusch and colleagues conducted a prospective, controlled and unblinded study to explore the effects of lutein / zeaxanthin supplementation and combined lutein / zeaxanthin supplementation and PUFA. The study included 79 patients over 50 years old with early or medium-term AMD, Only one eye of each patient was selected for the study (the eyes with severe disease were selected for the patients with both eyes). The patients were randomly divided into two groups, supplemented with lutein and antioxidant (vitaluxplus, number of cases 40) or lutein and antioxidant combined with PUFA (vitaluxomega, 39 cases) were followed up for 6 months and 12 months. Detailed ophthalmic examinations were performed at baseline, 1 month, 3 months, 6 months, 7 months, 8 months, 9 months and 12 months, including best corrected visual acuity, contrast sensitivity, mydriasis fundus examination, color fundus photography and MPOD determination. Lutein and zeaxanthin in serum were also measured Concentration of biotin., The results showed that the baseline level of MPOD in lutein group was 0.54 & plusmn; 0.19D. U. , 0.56 ± 0.19d in lutein + Omega group U.。 After 6 months of supplementation, the MPOD level increased to 0.66 ± 0.18 and 0.60 ± 0.22d in the two groups, respectively U., The change of lutein group was highly significant (P < 0.005), while the change of lutein + Omega group was not statistically significant (P = 0.059). During the one-year study, MPOD showed a slow downward trend (Fig. 1), and there was a statistical difference between the two groups (analysis of variance, P < 0.01). The baseline contrast sensitivity scores of the two groups were 1.29 ± 0.25 in lutein group and 1.23 ± 0.27 in lutein + Omega group respectively. After 6 months of study, the contrast sensitivity score of lutein group increased to 1.69 ± 0.22 (P < 0.01), but there was no significant change in lutein + Omega group (1.30 ± 0.25; P = 0.086), analysis of variance showed that there was significant difference between the two groups (P < 0.01). It should be noted that the contrast sensitivity decreased rapidly after the withdrawal of lutein group, but did not change after the withdrawal of lutein + Omega group. In addition, the levels of serum lutein and zeaxanthin only changed in the lutein supplemented group, but did not change in the combined lutein + Omega supplemented group. The difference between the two groups was statistically significant; the best corrected visual acuity of the two groups was in 6 months There was no change from baseline at month and 12 months of the study., The conclusion drawn from this study is that increasing polyunsaturated fatty acids will reduce the bioavailability of lutein, thus weakening the beneficial effect of the latter on macular pigment and contrast sensitivity, which is similar to the conclusion of some previous studies: monounsaturated fatty acids, such as olive oil, can increase the intestinal absorption of lutein, Fat rich in polyunsaturated fatty acids will reduce lutein intake. Therefore, this should be considered when providing lutein supplementation to patients with low lutein levels., OralLuteinSupplementationEnhancesMacularPigmentDensityandContrastSensitivitybutNotinCombinationWithPolyunsaturatedFattyAcids。 Wolf-SchnurrbuschUE,ZinkernagelMS,MunkMR,EbneterA,WolfS. InvestOphthalmolVisSci. 2015Dec1; 56(13):8069-74.,

macular pigment is composed of several kinds of carotenes, of which the most important two are lutein and zeaxanthin. It is speculated that macular pigment plays a protective role in the occurrence and progression of age-related macular lesions. One of the characteristics of macular pigment is its strong ability to absorb short wavelength blue light. Therefore, it can increase the visual acuity of macula and reduce the destructive photooxidation of light on neurosensory retina. Assuming that the formation of free radicals is the cause of age-related macular degeneration (AMD), high concentration of macular pigment density may prevent light-induced oxidative damage, on the contrary, the decrease of its density will increase the risk of AMD.

recently, some researchers discussed the role of omega-3 polyunsaturated fatty acid (PUFA) in the prevention of AMD. There are high levels of docosahexaenoic acid (DHA) in the outer disc membrane of photoreceptors. Although its role is not clear, it is believed that DHA and its precursor eicosapentaenoic acid (EPA) play an important role in the retina. Previous studies on the role of PUFA in the progression of AMD have not been conclusive. The recent age-related eye disease study 2 (areds2) shows that DHA + EPA has no beneficial effect on the progress of AMD. However, there are many supplements containing a large amount of Puma on the market, which are widely used to prevent and slow down the progress of AMD.

wolf schnurrbusch and colleagues carried out a forward-looking study