Treatment of dry eye with Runzao Mingmu Decoction

Abstract: dry eye is a general term for a class of diseases characterized by abnormal tear quality, quantity or dynamics caused by various reasons, leading to tear film instability and eye surface tissue lesions, accompanied by eye discomfort symptoms. Its main features are dry eyes, foreign body sensation, photophobia, blurred vision or vision fluctuation. Dry eye syndrome is one of the most common ocular surface diseases. With the improvement of people’s living standard, the incidence rate of dry eye has increased obviously, and has become a hot topic in international research.

The majority of patients with dry eye are computer workers, office workers and drivers, and have a younger trend.

and

in view of this, the author used the empirical formula runzaomingmu Decoction and local fumigation to treat computer dry eye with good curative effect. The treatment of this prescription is novel. It not only treats dry eye from the aspects of nourishing yin and generating fluid, clearing heat and moistening dryness, but also from the perspective of promoting blood circulation and removing blood stasis. The author reports the clinical efficacy of this prescription in the treatment of computer dry eye as follows:

1 data and methods

1. 1 general data

from March 2006 to September 2007, 60 outpatients with computer dry eye in our hospital were collected and randomly divided into treatment group and control group. 30 cases in the treatment group: 14 males and 16 females; The age ranged from 19 to 58 years, with an average of 45. 2 years old. 30 cases in the control group: male L7, female 13; The age ranged from 22 to 55 years, with an average of 47. 6 years old. There was no significant difference in gender and age between the two groups (P > 0.05).

  1。 2 diagnostic criteria

refer to the Research Report of the dry eye working group of the American Institute of Ophthalmology [2] and the relevant methods proposed by Zhang Hancheng and others [3], and formulate the following diagnostic criteria: ① symptoms, such as dry eyes, foreign body sensation, visual fatigue, and dry mouth and nose; ② Tear secretion (Schirmer method) was less than 10mm / 5min; ③ Tear film rupture time (but) < 10s; ④ Corneal fluorescein staining (FL) was positive. Two of the first three items are positive, which can be used as the case selection criteria.

  1。 3 inclusion criteria

and

meet the diagnostic criteria. Patients aged 18 ~ 60 can be included in the subjects, regardless of gender.

  1。 4 exclusion criteria

and

include: ① patients with acute ocular infection; ② Abnormal liver function, ALT > 40u / L, AST > 40u / L, renal insufficiency, CCR 176. eight μ mol/L,BUN>9mmol/L; ③ Those who are allergic or intolerant to the drugs used, and those who do not use the drugs according to the regulations; ④ Patients aged 60 years.

  1。 5 treatment methods

treatment group was given Runzao Mingmu decoction, consisting of 20g chamomile, 12g chrysanthemum, 18G Dendrobium, 15g raw land, 15g white peony and 9g Salvia miltiorrhiza. Take 1 dose per day after the first two decoctions, add 500ml of water each time, decoct 200ml, mix well and take it separately, twice a day; In the third decoction, 1000ml water was added, 600ml was decocted, and the affected eyes were fumigated while hot (prepared by the preparation room of the Second Affiliated Hospital of Guiyang University of traditional Chinese Medicine). In the control group, tearsnaturale II eye liquid (produced by the Belgian branch of Aierkang eye pharmaceutical factory) was topically applied, 3-6 times / D, 1-2 drops / time. The above two groups were treated for 1 month as a course of treatment.

2 Result

2. 1 Efficacy judgment

and

refer to the Research Report of the dry eye working group of the American Institute of Ophthalmology [2] and the diagnostic efficacy standard of traditional Chinese Medicine issued by the State Administration of traditional Chinese medicine [4]: take clinical symptoms, tear secretion, tear film rupture time and corneal fluorescein staining as observation indexes. ① Cure: the symptoms disappeared, the corneal staining disappeared, the Schirmer test measured more than 10mm / 5min for many times, and the tear film rupture time was more than 10s; ② Remarkable effect: the symptoms were significantly reduced, the corneal staining was reduced, the tear secretion was significantly increased by Schirmer test, and the tear film rupture time was prolonged; ③ Improvement: the symptoms were alleviated, the corneal staining was reduced, the tear secretion was increased by Schirmer test, and the tear film rupture time was prolonged; ④ Invalid: no improvement in symptoms, no change in corneal staining, no increase in tear secretion and no change in tear film rupture time determined by schirme test for many times.

  2。 2 treatment results

treatment group: 15 cases were markedly effective, 13 cases were effective, 2 cases were ineffective, and the effective rate was 93. 3%; Control group: 10 cases were markedly effective, 12 cases were effective, 8 cases were ineffective, and the effective rate was 73. 3%。 There was significant difference between the two groups (P < 0.05).

3 discussion

dry eye syndrome [5] refers to a general term for a class of diseases characterized by abnormal tear quality, quantity or dynamics caused by various reasons, leading to tear film instability and ocular surface tissue lesions, accompanied by ocular discomfort symptoms. Its main features are dry eyes, foreign body sensation, photophobia, blurred vision or vision fluctuation. In severe cases, it can cause vision loss or even blindness. Traditional Chinese medicine believes that the pathogenesis lies in the deficiency of liver and kidney yin, the endogenous dryness and heat, the loss of nourishment of the eyes, and the endogenous blood stasis and aggravation of the disease due to the homology of body fluid and blood and the loss of body fluid and blood. The nature of the disease is deficiency and excess. The deficiency is mainly responsible for deficiency of liver and kidney yin, and the excess is mainly responsible for dryness, heat and blood stasis. Therefore, the treatment should be based on Nourishing Yin and generating fluid, clearing heat and moistening dryness, promoting blood circulation and removing blood stasis. The empirical formula Runzao Mingmu Decoction (20g of Herba Cassiae, 12g of chrysanthemum, 18G of Dendrobium, 15g of Radix rehmanniae, 15g of Radix Paeoniae Alba and 9g of Radix Salviae Miltiorrhizae) contains Herba Cassiae, chrysanthemum clearing liver and brightening eyes, Dendrobium nourishing yin and removing heat and brightening eyes, Radix Paeoniae Alba clearing heat and cooling blood stasis, Danshen cooling blood stasis, and Radix Rehmanniae clearing heat and cooling blood. All drugs are used together to nourish yin, generate fluid, clear heat and moisten dryness The power of promoting blood circulation and removing blood stasis. The results of this group showed that the decoction could be applied to the treatment of the eye with fumigating and fumigation. It could be applied to hyperthermia in order to promote the circulation of tears, thereby promoting the secretion of tears, improving the nutritional status of the eye tissues, taking the function of clearing away heat and detoxifying the Chinese herbal medicine, and cleaning up the spray.

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, Abstract: dry eye refers to a kind of disease characterized by abnormal tear quality, quantity or dynamics caused by various reasons, leading to tear film instability and ocular surface tissue lesions, accompanied by ocular discomfort symptoms. Its main features are dry eyes, foreign body sensation, photophobia, blurred vision or vision fluctuation., Dry eye is one of the most common ocular surface diseases. With the improvement of people’s living standard, the incidence rate of dry eye has increased obviously, and has become a hot topic in international research. The majority of patients with dry eye are computer workers, office workers and drivers, and have a younger trend., In view of this, the author used the empirical formula runzaomingmu Decoction and local fumigation to treat computer dry eye with good curative effect. The treatment of this prescription is novel. It not only treats dry eye from the aspects of nourishing yin and generating fluid, clearing heat and moistening dryness, but also from the perspective of promoting blood circulation and removing blood stasis. The author has observed the clinical effect of the prescription in treating xerophthalmia. It is reported as follows: 1 data and methods,

dry eye is one of the most common ocular surface diseases. With the improvement of people’s living standard, the incidence rate of dry eye has increased obviously, and computer vision has become a hot topic in international research. The majority of patients with dry eye are computer workers, office workers and drivers, and have a younger trend.

and

in view of this, the author used the empirical formula runzaomingmu Decoction and local fumigation to treat computer dry eye with good curative effect. The treatment of this prescription is novel. It not only treats dry eye from the aspects of nourishing yin and generating fluid, clearing heat and moistening dryness, but also from the perspective of promoting blood circulation and removing blood stasis. The author reports the clinical efficacy of this prescription in the treatment of computer dry eye as follows:

1 data and methods

1. 1 general data

from March 2006 to September 2007, 60 outpatients with computer dry eye in our hospital were collected and randomly divided into treatment group and control group. 30 cases in the treatment group: 14 males and 16 females; The age ranged from 19 to 58 years, with an average of 45. 2 years old. 30 cases in the control group: male L7, female 13; The age ranged from 22 to 55 years, with an average of 47. 6 years old. There was no significant difference in gender and age between the two groups (P > 0.05).

  1。 2 diagnostic criteria

refer to the Research Report of the dry eye working group of the American Institute of Ophthalmology [2] and the relevant methods proposed by Zhang Hancheng and others [3], and formulate the following diagnostic criteria: ① symptoms, such as dry eyes, foreign body sensation, visual fatigue, and dry mouth and nose; ② Tear secretion (Schirmer method) was less than 10mm / 5min; ③ Tear film rupture time (but) < 10s; ④ Corneal fluorescein staining (FL) was positive. Two of the first three items are positive, which can be used as the case selection criteria.

  1。 3 inclusion criteria

and

meet the diagnostic criteria. Patients aged 18 ~ 60 can be included in the subjects, regardless of gender.

  1。 4 exclusion criteria

and

include: ① patients with acute ocular infection; ② Abnormal liver function, ALT > 40u / L, AST > 40u / L, renal insufficiency, CCR 176. eight μ mol/L,BUN>9mmol/L; ③ Those who are allergic or intolerant to the drugs used, and those who do not use the drugs according to the regulations; ④ Patients aged 60 years.

  1。 5 treatment methods

treatment group was given Runzao Mingmu decoction, consisting of 20g chamomile, 12g chrysanthemum, 18G Dendrobium, 15g raw land, 15g white peony and 9g Salvia miltiorrhiza. Take 1 dose per day after the first two decoctions, add 500ml of water each time, decoct 200ml, mix well and take it separately, twice a day; In the third decoction, 1000ml water was added, 600ml was decocted, and the affected eyes were fumigated while hot (prepared by the preparation room of the Second Affiliated Hospital of Guiyang University of traditional Chinese Medicine). In the control group, tearsnaturale II eye liquid (produced by the Belgian branch of Aierkang eye pharmaceutical factory) was topically applied, 3-6 times / D, 1-2 drops / time. The above two groups were treated for 1 month as a course of treatment.

2 Result

2. 1 Efficacy judgment

According to the Research Report of the dry eye working group of the American Institute of Ophthalmology [2] and the diagnostic efficacy standard of traditional Chinese Medicine issued by the national administration of traditional Chinese medicine [4]: the clinical symptoms, tear secretion, tear film rupture time and corneal fluorescein staining were observed. ① Cure: the symptoms disappeared, the corneal staining disappeared, the Schirmer test measured more than 10mm / 5min for many times, and the tear film rupture time was more than 10s; ② Remarkable effect: the symptoms were significantly reduced, the corneal staining was reduced, the tear secretion was significantly increased by Schirmer test, and the tear film rupture time was prolonged; ③ Improvement: the symptoms were alleviated, the corneal staining was reduced, the tear secretion was increased by Schirmer test, and the tear film rupture time was prolonged; ④ Invalid: no improvement in symptoms, no change in corneal staining, no increase in tear secretion and no change in tear film rupture time determined by schirme test for many times.

  2。 2 treatment results

treatment group: 15 cases were markedly effective, 13 cases were effective, 2 cases were ineffective, and the effective rate was 93. 3%; Control group: 10 cases were markedly effective, 12 cases were effective, 8 cases were ineffective, and the effective rate was 73. 3%。 There was significant difference between the two groups (P < 0.05).

3 discussion

dry eye syndrome [5] refers to a general term for a class of diseases characterized by abnormal tear quality, quantity or dynamics caused by various reasons, leading to tear film instability and ocular surface tissue lesions, accompanied by ocular discomfort symptoms. Its main features are dry eyes, foreign body sensation, photophobia, blurred vision or vision fluctuation. In severe cases, it can cause vision loss or even blindness. Traditional Chinese medicine believes that the pathogenesis lies in the deficiency of liver and kidney yin, the endogenous dryness and heat, the loss of nourishment of the eyes, and the endogenous blood stasis and aggravation of the disease due to the homology of body fluid and blood and the loss of body fluid and blood. The nature of the disease is deficiency and excess. The deficiency is mainly responsible for deficiency of liver and kidney yin, and the excess is mainly responsible for dryness, heat and blood stasis. Therefore, the treatment should be based on Nourishing Yin and generating fluid, clearing heat and moistening dryness, promoting blood circulation and removing blood stasis. The empirical formula Runzao Mingmu Decoction (20g of Herba Cassiae, 12g of chrysanthemum, 18G of Dendrobium, 15g of Radix rehmanniae, 15g of Radix Paeoniae Alba and 9g of Radix Salviae Miltiorrhizae) contains Herba Cassiae, chrysanthemum clearing liver and brightening eyes, Dendrobium nourishing yin and removing heat and brightening eyes, Radix Paeoniae Alba clearing heat and cooling blood stasis, Danshen cooling blood stasis, and Radix Rehmanniae clearing heat and cooling blood. All drugs are used together to nourish yin, generate fluid, clear heat and moisten dryness The power of promoting blood circulation and removing blood stasis. The results of this group showed that the decoction could be applied to the treatment of the eye with fumigating and fumigation. It could be applied to hyperthermia in order to promote the circulation of tears, thereby promoting the secretion of tears, improving the nutritional status of the eye tissues, taking the function of clearing away heat and detoxifying the Chinese herbal medicine, and cleaning up the spray.

,  1。 General data: from March 2006 to September 2007, 60 outpatients with computer dry eye in our hospital were collected and randomly divided into treatment group and control group. 30 cases in the treatment group: 14 males and 16 females; The age ranged from 19 to 58 years, with an average of 45. 2 years old. 30 cases in the control group: male L7, female 13; The age ranged from 22 to 55 years, with an average of 47. 6 years old. There was no significant difference in gender and age between the two groups (P > 0.05).,   1。 2 diagnostic criteria: according to the Research Report of the dry eye working group of the American Institute of Ophthalmology [2] and the relevant methods proposed by Zhang Hancheng and others [3], the following diagnostic criteria are formulated: ① symptoms, such as dry eyes, foreign body sensation, visual fatigue, and dry mouth and nose; ② Tear secretion (Schirmer method) was less than 10mm / 5min; ③ Tear film rupture time (but) 40u / L, AST > 40u / L, renal insufficiency, CCR 176. eight μ mol/L,BUN>9mmol/L; ③ Those who are allergic or intolerant to the drugs used, and those who do not use the drugs according to the regulations; ④ Patients aged 60 years.,   1。 5 treatment methods: the treatment group was given Runzao Mingmu decoction, consisting of 20g cassia, 12g chrysanthemum, 18G Dendrobium, 15g raw land, 15g white peony and 9g Salvia miltiorrhiza. Take 1 dose per day after the first two decoctions, add 500ml of water each time, decoct 200ml, mix well and take it separately, twice a day; In the third decoction, 1000ml water was added, 600ml was decocted, and the affected eyes were fumigated while hot (prepared by the preparation room of the Second Affiliated Hospital of Guiyang University of traditional Chinese Medicine). In the control group, tearsnaturale II eye liquid (produced by the Belgian branch of Aierkang eye pharmaceutical factory) was topically applied, 3-6 times / D, 1-2 drops / time. The above two groups were treated for 1 month as a course of treatment., 2 results, 2. 1. The efficacy was determined according to the Research Report of the dry eye working group of the American Institute of Ophthalmology [2] and the diagnostic efficacy standard of traditional Chinese Medicine issued by the national administration of traditional Chinese medicine [4]: the clinical symptoms, tear secretion, tear film rupture time and corneal fluorescein staining were observed. ① Cure: the symptoms disappeared, the corneal staining disappeared, the Schirmer test measured more than 10mm / 5min for many times, and the tear film rupture time was more than 10s; ② Remarkable effect: the symptoms were significantly reduced, the corneal staining was reduced, the tear secretion was significantly increased by Schirmer test, and the tear film rupture time was prolonged; ③ Improvement: the symptoms were alleviated, the corneal staining was reduced, the tear secretion was increased by Schirmer test, and the tear film rupture time was prolonged; ④ Invalid: no improvement in symptoms, no change in corneal staining, no increase in tear secretion and no change in tear film rupture time determined by schirme test for many times.,   2。 2 treatment node