Abstract: if both parents are myopic, 33% ~ 60% of children are myopic; One of the parents is myopic, and 23 ~ 40% of the children are myopic; Parents are not myopic, and only 6 ~ 15% of their children are myopic., Xiaobian always has some such friends around him. When he was a child, he hid under the quilt and read comic books. When he grew up, he held a mobile phone and computer every day, but he was not short-sighted; And other friends, young age is high myopia? Why? Is gene really so unfair? A regrettable study shows that if you have a myopia gene, it’s really hard not to be short-sighted., Contrary to the traditional view, the current mainstream view in the medical community is that myopia mostly depends on genes. The heritability of myopia is as high as 0.9 (1 indicates that it is completely determined by genes, and 0 indicates that it has nothing to do with genes). Bad eye habits only induce myopia, which is not the root cause of myopia. People without myopia genes will not be myopia no matter how they use their eyes (some vicious cases are not ruled out), and people with myopia genes will become myopic if they don’t pay attention to it. It’s almost impossible to prevent it in the environment where high-intensity eye use is required in modern life. Tips: the heritability rate is 0.9. It doesn’t mean that parents are myopic, and children are 90% likely to be myopic. It means that the ratio of genetic variance to phenotype variance of myopia is 0.9. It’s understandable For, myopia or not, the vast majority of congenital decisions have been made, but may not be consistent with their parents., If both parents are myopic, 33% ~ 60% of the children are myopic; One of the parents is myopic, and 23 ~ 40% of the children are myopic; Parents are not myopic, and only 6 ~ 15% of their children are myopic., Myopia is not controlled by a single gene. Although there is a correlation between parents, children and non identical brothers and sisters, the correlation coefficient must be much lower than that of identical twins., Take the paper data as an example:
Xiaobian always has some such friends around him. When he was a child, he hid under the quilt and read comic books. When he grew up, he held a mobile phone and computer every day, but he was not short-sighted; And other friends, young age is high myopia? Why? Is gene really so unfair? A regrettable study shows that if you have a myopia gene, it’s really hard not to be short-sighted.
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are contrary to the traditional view. At present, the mainstream view in the medical community is that myopia mostly depends on genes. The heritability of myopia is as high as 0.9 (1 indicates that it is completely determined by genes, and 0 indicates that it has nothing to do with genes). The bad eye habits of
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just induce myopia, which is not the root cause of myopia. People without myopia genes will not be myopia no matter how they use their eyes (vicious cases are not excluded), and people with myopia genes will become myopic if they pay little attention, which is almost impossible to prevent in the environment of high-intensity eye use in modern life.
tips
The heritability of 0.9 does not mean that parents are nearsighted, and children are 90% likely to be nearsighted. Instead, the ratio of genetic variance to phenotypic variance of myopia is 0.9. It can be understood that myopia has been determined by most congenital factors, but it may not be consistent with parents.
if both parents are myopic, 33% ~ 60% of the children are myopic; One of the parents is myopic, and 23 ~ 40% of the children are myopic; Parents are not myopic, and only 6 ~ 15% of their children are myopic.
myopia is not controlled by a single gene. Although there is a correlation between parents, children and non identical brothers and sisters, the correlation coefficient must be much lower than that of identical twins.
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take the data of the paper as an example:
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are the three myopia indexes se (equivalent sphericity), Al (axial length) and ACD (central anterior chamber depth). On the left are identical twins with exactly the same genes. On the right are fraternal twins with the same genetic similarity as non twin siblings. Both groups were twins, so it can be considered that the interference of environmental factors was excluded. It can be seen from the figure that the myopia correlation of identical twins is much greater than that of fraternal twins.